The brothers of Yosef Hatzadik were פוגם the middah of Yesod [sexual purity] because when you start up with the quintessential Tzadik - you are starting up with Yesod. צדיק יסוד עולם. When people fall in matters related to Yesod, they are invariably depressed. A major, documented cause of depression is the relentless pursuit of base sexual pleasure. It may feel good for a few moments but afterwards the depression sets in. Just ask [possibly] the greatest sex symbol of the 20th century, Marilyn Monroe. But you can't ask her - because she killed herself.
When religious men fall in this area they are especially shattered. So many yeshiva bochrim battle and all too often .... lose. For another time I hope but back to our main point.
So when Yosef met his brothers he wanted to make them feel better after they had blemished their Yesod [i.e. Yosef Hatzadik] so he said to them "אל תעצבו" - don't be sad!!! [See the sefer מסילות בלבבם פרשת וארא].
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From the Shem Mi-shmuel - MOIRA-DIK!!!