There are 248 words in Shema which are preceded by the words "Hashem Echad". This implies that all 248 limbs in our body [which correspond to the mitzvos] are really one organic unit - we just don't see it. The whole notion of "holistic medicine" where a disease in one organ or limb is perceived as a disease in the entire organism has a source in this idea. At the end of days we will see how all 248 [positive] mitzvos were really one, how our entire body is interconnected and how the the mitzvos relate to our bodies.
Everything is One!!!
[עי' בס' ואני תפילה עמ' ט"ז]
