There is an interesting opinion of the Rambam who says that we ALL have the status of prutzim and therefore a woman may not seclude herself with 2 men or more. This is based on the gemara that relates that Rav maintained that both he and Rav Yehudah have the status of prutzim and non-prutzim would only be someone like Rebbe Chanina bar Papi and his friends who were really holy.
Two men and two woman is the subject of a dispute. Three and three is definitely cool [permitted].